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E1906 Sigma-Aldrich

Anti-EAPII (TTRAP) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ETS1-associated Protein 2, Anti-TRAF and TNF Receptor Associated Protein

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies for Epigenetics and Nuclear Signaling,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:1,000-1:5,000
species reactivity   human
mol wt   antigen mol wt ~41 kDa by calculation
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
Gene Information   human ... TTRAP(51567)

Description

Immunogen

peptide corresponding to the human EAPII (amino acids 11-28).

Application

Anti-EAPII (TTRAP) antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:1000-1:5000.

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Ets proteins are a family of conserved sequence specific DNA-binding proteins. They function as transcription factors with roles in differentiation, lymphoid cell development, invasiveness, and angiogenesis. ETS1-associated protein II (EAPII) interacts with ETS1 and other Ets proteins (ETS2 and FLI1). EAPII is mainly localized to the nucleus of mammalian cells. EAPII negatively modulates the transcriptional activity of ETS1. It reduces synergistic transactivation by ETS1 and AP-1. Re-expression of EAPII prevents the migration of epithelial cancer cells. It does not affect cell viability.

Safety & Documentation

Safety Information

WGK Germany 
3

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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