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E3763 Sigma-Aldrich

Resorufin ethyl ether

Synonym: 7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin

  • CAS Number 5725-91-7

  • Empirical Formula (Hill Notation) C14H11NO3

  • Molecular Weight 241.24

  •  Beilstein/REAXYS Number 225973

  •  MDL number MFCD00037661

  •  PubChem Substance ID 24894527

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Description

General description

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.

Application

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

Packaging

1, 5 mg in glass bottle

Substrates

Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues...
Robert Gates
Biofiles Volume 6 Article 1
Keywords: Catalysis, Eliminations, Environmental, Enzyme-linked immunosorbent assay, Gastrointestinal, Gene expression, Immunohistochemistry, Metabolism, Metabolites, Oxidations, Post translational modifications, Reductions, Support, Western blot

Peer-Reviewed Papers
15

References

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