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  • E4141 - Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse

E4141 Sigma

Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse

clone AS61, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-EDG-3, Anti-Endothelial Cell Differentiation Gene 3, C-Terminal



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   rat, human
application(s)   western blot: 1:10,000 using human and rat spleen and lung tissue
clone   AS61, monoclonal
concentration   ~1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG
mol wt   antigen mol wt 45 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... S1PR3(1903)
rat ... Edg3l(29736)
biological source   mouse
conjugate   unconjugated



human EDG-3/S1P3 unique C-terminal peptide.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.


Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse is suitable for western blotting at a dilution of 1:10,000 using human and rat spleen and lung tissue.

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Biochem/physiol Actions

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR3 acts as a critical signaling molecule mediating cell proliferation and vascular permeability. It acts as a potential biomarker in murine and human acute lung injury (ALI). Sphingosine 1-phosphate (S1P) and the S1P receptor S1PR3 are intimately involved in lung inflammatory responses and vascular barrier regulation. S1PR3 serves as a biomarker of severity in critically acute respiratory distress syndrome (ARDS) patients and can act as a potential target for individualized therapy.

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Certificate of Analysis

Certificate of Origin

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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