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  • E4767 - Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse

E4767 Sigma

Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse

clone AS65, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5, C-Terminal



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   human, rat
application(s)   western blot: suitable
clone   AS65, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG
mol wt   antigen mol wt ~45 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... S1PR2(9294)
rat ... S1pr2(29415)
biological source   mouse
conjugate   unconjugated



human EDG-5/S1P2 unique C-terminal peptide.

Antigen Background

EDG-5/S1P2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P2 is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue.

Preparation Note

Purified from in vitro cell culture supernatants using protein A.


Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung.

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Biochem/physiol Actions

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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