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E4786 Sigma-Aldrich

Escitalopram oxalate

≥98% (HPLC), powder

Synonym: S-(+)-Citalopram oxalate, S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate

  • CAS Number 219861-08-2

  • Empirical Formula (Hill Notation) C20H21FN2O · C2H2O4

  • Molecular Weight 414.43

  •  MDL number MFCD06407826

  •  PubChem Substance ID 329799062

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥15 mg/mL
originator   Forest Labs
storage temp.   2-8°C
SMILES string   OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
InChI   1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1
InChI key   KTGRHKOEFSJQNS-BDQAORGHSA-N
Gene Information   human ... SLC6A4(6532)

Description

General description

Escitalopram oxalate is an anti-depressant. It is used to treat panic disorder and major depressive disorder(MDD).

Application

Escitalopram oxalate has been used as an antidepressant in rats exposed to chronic mild stress (CMS). It has also been used for scintillation proximity-based thermostability assay.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.

Features and Benefits

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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