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E5406 Sigma-Aldrich

Ethopropazine hydrochloride

≥98% (HPLC), powder

Synonym: 10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin

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Properties

Related Categories Analytical and Industrial Enzymes, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: >5 mg/mL at ~60 °C, clear
originator   Pfizer
storage temp.   2-8°C
SMILES string   Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13
InChI   1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
InChI key   VXPCQISYVPFYRK-UHFFFAOYSA-N
Gene Information   human ... CHRM1(1128)

Description

General description

Ethopropazine hydrochloride possess anticholinergic, antihistamine and antiadrenergic properties.

Packaging

50, 250 mg in glass bottle

Biochem/physiol Actions

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SO5002000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In the nervous system, this enzyme is thought to exist primarily in the nerve terminal cytopla...
Keywords: Clinical, Enzyme activity, Insecticides, Phosphorylations, Transcription

Peer-Reviewed Papers
15

References

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