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  • E5892 - Anti-EphB1 (ELK Receptor)-EXT antibody produced in sheep

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E5892 Sigma-Aldrich

Anti-EphB1 (ELK Receptor)-EXT antibody produced in sheep

purified immunoglobulin, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
conjugate   unconjugated
clone   polyclonal
biological source   sheep
application(s)   immunoprecipitation (IP): 10-20 μg/mL
  western blot (chemiluminescent): 1-10 μg/mL
species reactivity   human
mol wt   antigen 116 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   purified immunoglobulin
antibody product type   primary antibodies
UniProt accession no.   P54762
Gene Information   human ... EPHB1(2047)

Description

General description

Eph family of tyrosine kinase receptors mediates cell-cell attachment and aggregation by binding to specific ligands, ephrins. The Eph family consists of 14 structurally related receptors that are either membrane linked or are transmembrane with overlapping affinity for ligands. The transmembrane receptors EphA and EphB1 (ELK) subclasses signal via distinct mediators in the cytoplasm. EphB1 binds ephrinB1, recruits Grb2 and Grb10 and mediates cell attachment and cell-cell assembly. Activated EphB1 also reportedly mediates the signaling by c-Jun kinase. The EphB1 receptors are vital in targeting the migration of neurons, angiogenesis and vascular cell assembly during development
Anti-EphB1 (Elk Receptor)-EXT recognizes the external region of human EphB1 protein (116 kDa).

Immunogen

GST-fusion protein EphB1 (Elk Receptor)-EXT corresponding to amino acids 16-351 of the N-terminal region.

Application

Anti- EphB1 (ELK Receptor)-EXT antibody may be used for immunoblotting at a working concentration of 1-10 μg/ml. Antibody concentration of 10-20 μg/ml is recommended for immunoprecipitation.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
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References

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