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E7280 Sigma-Aldrich

Elafin human

>90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
recombinant   expressed in Saccharomyces cerevisiae
assay   >90% (by MS, HPLC and SDS-PAGE)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C
Gene Information   human ... PI3(5266)

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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