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E8031 Sigma-Aldrich

Esmolol hydrochloride

≥98% (HPLC), solid

Synonym: 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Baxter, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
mp   89.0-90.6 °C
solubility   H2O: 12 mg/mL
originator   Baxter
storage temp.   2-8°C
SMILES string   Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
InChI   1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H
InChI key   GEKNCWBANDDJJL-UHFFFAOYSA-N
Gene Information   human ... ADRB1(153), ADRB2(154)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Esmolol hydrochloride is a ultrashort-acting β1 adrenoceptor antagonist (β1 receptor occupancy = 84.7%).

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
DA8346000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

β-Adrenoceptors

β-Adrenoceptors are widely distributed, found at both central and peripheral sites, and are activated either via norepinephrine released from sympathetic terminals or via epinephrine (E4250, E4375) r...
Keywords: Antihypertensives, Atomic absorption spectroscopy, Diabetes, Gene expression, Neurotransmitters, Obesity, Reductions, Transduction

Peer-Reviewed Papers
15

References

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