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E9038 Sigma-Aldrich

Cytochrome P450 3A4 human

recombinant, expressed in Saccharomyces cerevisiae

Synonym: Cerosomes, Cytochrome P450 Microsome Preparation human

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cytochrome P450 human recombinant microsome preparations, Cytochrome P450s (CYPs),
biological source   human
recombinant   expressed in Saccharomyces cerevisiae
form   liquid
specific activity   ≥5 units/pmol enzyme
secondary activity   ≥50 units/mg protein (Reductase activity)
concentration   ≥5 mg/mL protein (Bradford)
  1 pmol/μL
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CYP3A4(1576)

Description

General description

Microsome contents of CYP3A4 human and CYP-reductase human expressed in Saccharomyces cerevisiae mixed with Cytochrome B5 human.

Unit Definition

P450 Activity: One unit will oxidize 1 picomole of testosterone per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.

Physical form

50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol

Other Notes

For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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