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E9406 Sigma-Aldrich

Epirubicin hydrochloride

≥90% (HPLC)

Synonym: 4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride

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Properties

biological source   synthetic
InChI Key   MWWSFMDVAYGXBV-FGBSZODSSA-N
assay   ≥90% (HPLC)
form   powder
color   red to deep red
solubility   H2O: soluble
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   neoplastics
storage temp.   −20°C

Description

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Packaging

5, 10 mg in glass bottle

Biochem/physiol Actions

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QI9295750

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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