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  • E9538 - Cytochrome P450 2C9 human

E9538 Sigma-Aldrich

Cytochrome P450 2C9 human

recombinant, expressed in Saccharomyces cerevisiae

Synonym: Cerosomes, Cytochrome P450 Microsome Preparation human



Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cytochrome P450 human recombinant microsome preparations, Cytochrome P450s (CYPs),
Quality Level   200
biological source   human
recombinant   expressed in Saccharomyces cerevisiae
form   liquid
specific activity   ≥10 units/pmol enzyme (P450)
secondary activity   ≥500 units/mg protein (Reductase activity)
concentration   ≥10 mg/mL protein (Bradford)
  1 pmol/μL (P450)
application(s)   cell analysis: suitable
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CYP2C9(1559)


General description

Microsome contents of CYP2C9 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.


Recombinant cytochrome P450, isozyme 2C9, (CYP2C9) may be used in toxicity and drug metabolism/ pharmacokinetics research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2C9, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs such as warfarin, bosentan, and fluoxetine.

Unit Definition

P450 Activity: One unit will oxidize 1 picomole of diclofenac per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.

Physical form

50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol

Other Notes

For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers


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