• USA Home
  • EPI008 - Histone Deacetylase (HDAC) Inhibitor Set I

EMAIL THIS PAGE TO A FRIEND
EPI008 Sigma-Aldrich

Histone Deacetylase (HDAC) Inhibitor Set I

Set includes 6 inhibitors

Purchase

Description

General description

A convenient set of six selected individual HDAC (Histone Deacetylase) inhibitors.
• Apicidin
CAS Number: 183506-66-3
Molecular Formula: C34H49N5O6
Molecular Weight: 623.8
• M344
CAS Number: 251456-60-7
Molecular Formula: C16H25N3O3
Molecular Weight: 307.39
• Sodium 4-phenylbutuyrate
CAS Number: 1716-12-7
Molecular Formula: C10H11O2·Na
Molecular Weight: 186.2
• Splitomycin
CAS Number: 5690-03-9
Molecular Formula: C13H10O2
Molecular Weight: 198.2
• Trichostatin A
CAS Number: 58880-19-6
Molecular Formula: C17H22N2O3
Molecular Weight: 302.4
• Valproic Acid, Sodium Salt
CAS Number: 1069-66-5
Molecular Formula: C8H15O2·Na
Molecular Weight: 166.19

Biochem/physiol Actions

• Apicidin - A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner.
• M344 - An amide analog of Trichostatin A that potently Inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.
• Sodium 4-phenylbutuyrate - Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
• Splitomycin - Potent inhibitor of yeast NAD+ dependent histone deacetylase Sir2p (IC50= 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
• Trichostatin A - Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.
• Valproic acid sodium salt - A cell-permeable histone deacetylase 1 (HDAC1) inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective properties. Recently it has been reported that Valproic acid enables reprogramming of primary human fibroblasts with only two factors, Oct4 and Sox2, without the need for the oncogenes c-Myc or Klf4.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Precautionary statements 
RIDADR 
UN 3316 9

Documents

Certificate of Analysis

Please Enter a Lot Number
Protocols & Articles
Related Products

related product

Product #

Description

Add to Cart

390585 Suberohydroxamic acid, 95%
S4068 Splitomicin, ≥98% (HPLC), powder
S7817 Scriptaid, ≥95%, solid
A2478 APHA Compound 8, ≥98% (HPLC), solid
O3139 Oxamflatin, ≥98% (HPLC), solid
B4061 BATCP, ≥98% (HPLC), solid
P5874 PTACH, ≥98% (HPLC), solid
M2195 MOCPAC, ≥95% (HPLC), solid
M5820 M344, ≥98% (HPLC), powder
T1952 Trichostatin A, Ready Made Solution, 5 mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
C0494 Cambinol, ≥97% (HPLC), white powder
C0621 CI−994, ≥98% (HPLC), powder
T2580 Trapoxin A, ≥98% (HPLC), from Helicoma ambiens
T8552 Trichostatin A, ≥98% (HPLC), from Streptomyces sp.
P4543 Valproic acid sodium salt, 98%
EPS002 MS-275, A HDAC1 and HDAC3 inhibitor
EPS003 CUDC 101, A potent inhibitor of HDACs and receptor tyrosine kinases
B5887 Sodium butyrate, ≥98.5% (GC)
R5010 Resveratrol, ≥99% (HPLC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?