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EPS002 Sigma-Aldrich

MS-275

A HDAC1 and HDAC3 inhibitor

Synonym: 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, MS-275 (Entinostat, SNDX-275), N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

  • CAS Number 209783-80-2

  • Empirical Formula (Hill Notation) C21H20N4O3

  • Molecular Weight 376.41

  •  MDL number MFCD03453552

  •  PubChem Substance ID 329799578

  •  NACRES NA.41

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Properties

Related Categories Bioactive Small Molecules for Epigenetic Research, Epigenetics, Histone Deacetylase Inhibitors, Molecular Biology, Other HDAC Inhibitors More...
Quality Level   100
assay   ≥99%
solubility   DMSO: 38 mg/mL
storage temp.   −20°C
SMILES string   Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
InChI   1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChI key   INVTYAOGFAGBOE-UHFFFAOYSA-N
Gene Information   human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

Description

General description

Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM).

Application

MS-275 has been used as a histone deacetylase-1 inhibitor.

Biochem/physiol Actions

HDAC inhibitor; antiproliferative.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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