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F0287 Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 70 kDa

Synonym: Fibronectin

  •  MDL number MFCD00131062

  •  eCl@ss 42020141

  •  NACRES NA.75



Related Categories Application Index, Attachments Factors, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
Quality Level   200
biological source   human plasma
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   70 kDa
packaging   pkg of 0.5 mg
application(s)   cell culture | mammalian: suitable
impurities   HIV and HBsAg, source material tested negative
  Small proteolytic fragments, may contain traces
solubility   water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless
shipped in   ambient
storage temp.   −20°C
Gene Information   human ... FN1(2335)


General description

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.


Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

Biochem/physiol Actions

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.


The product should be stored at -20°C.

Preparation Note

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


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What is the Extracellular Matrix?

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Keywords: Adhesion, Cell culture, Cellular processes, Epimerizations, Growth factors, Immobilization, Sulfations

Peer-Reviewed Papers


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