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F0682 Sigma-Aldrich

Anti-FNTB (21-35) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-FPTB, Anti-Protein farnesyltransferase subunit β

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Properties

Related Categories Alphabetical Index, Antibodies, FK-FO, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:500-1:2,000
species reactivity   human
mol wt   antigen ~49 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
UniProt accession no.   P49356
Gene Information   human ... FNTB(2342)

Description

Immunogen

synthetic peptide corresponding to amino acids 21-35 of human FNTB

Application

Anti-FNTB (21-35) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Protein farnesyltransferase subunit β is an enzyme encoded by the FNTB gene in humans and is located on human chromosome bands 14q23-q24. It helps in catalyzing the biologically relevant lipidation of cellular proteins. FTase may play an important role in the genesis and development of primary liver cancer (PLC). It may act as a reliable marker for the metastatic activity gained by liver tumor cells. FTase may be used clinically in predicting metastatic recurrence of PLC. Farnesyl protein transferase (FPTase) inhibitors (FTIs) were also developed as potential anticancer agents targeting the ras oncogene and also for parasitic infections.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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