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F1147 Sigma-Aldrich

Fumonisin B1 from Fusarium moniliforme

≥98% (HPLC)

Synonym: Macrofusine

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Description

General description

Fumonisin B1 is a mycotoxin found in the fungus Fusarium moniliforme,and this toxin can also be obtained from corn infected with the same fungus. It shares similarities with sphingosine and okadaic acid (OA).

Application

Fumonisin B1 from Fusarium moniliforme has been used:
• as a standard in the analysis of mycotoxins in caecal content obtained from adult pigs
• in the study of the effect of fumonisin B1 on the metabolism of prion protein (PrP) isoforms and the synthesis of scrapie prion protein PrPSc and
• in the study of the toxic effects of fumonisin B1 on explants obtained from pig jejunum.

Biochem/physiol Actions

Fumonisin B1 acts as a hepatocarcinogen and causes hepatotoxicity in rats. In horses, it causes leukoencephalitis, and in pigs, it causes pulmonary edema syndrome. In China and southern parts of Africa, it is linked with high incidence of esophageal cancer in humans. It acts as an inhibitor of sphingosine N-acyltransferase enzyme.

Fungal metabolite believed to cause leukoencephalomalacia in horses.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TZ8350000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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