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F1293 Sigma-Aldrich

Finasteride

≥98% (HPLC), powder

Synonym: N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, MK-906

  • CAS Number 98319-26-7

  • Empirical Formula (Hill Notation) C23H36N2O2

  • Molecular Weight 372.54

  •  MDL number MFCD00869737

  •  PubChem Substance ID 24724479

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble >20 mg/mL
storage temp.   room temp
SMILES string   [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
InChI   1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChI key   DBEPLOCGEIEOCV-WSBQPABSSA-N
Gene Information   human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

Description

Application

Finasteride has been used:
• as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
• in culture medium to treat tumor cells in vitro
• as a positive control to treat benign prostatic hyperplasia (BPH)
• to examine its effect on structural and molecular biology on the ventral prostate of senile mice

Packaging

100 mg in glass bottle

Biochem/physiol Actions

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

Selective 5α-reductase inhibitor; antiandrogen.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F1293.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
CL5245000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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References

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