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F1553 Sigma-Aldrich

S-(+)-Fluoxetine hydrochloride

≥98% (HPLC), solid

  • CAS Number 114247-06-2

  • Empirical Formula (Hill Notation) C17H18NOF3 · HCl

  • Molecular Weight 345.79

  •  MDL number MFCD04040001

  •  PubChem Substance ID 24278432

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,
InChI Key   GIYXAJPCNFJEHY-NTISSMGPSA-N
assay   ≥98% (HPLC)
form   solid
color   white
solubility   H2O: soluble ≥20 mg/mL
originator   Eli Lilly
storage temp.   room temp
Gene Information   human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Description

Biochem/physiol Actions

Selective serotonin reuptake inhibitor.

Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.

Packaging

5, 25 mg in glass bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Fluoxetine hydrochloride or fluoxetine hcl is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac®.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Prozac is a registered trademark of Eli Lilly and Co.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

GC Analysis of Fluoxetine Enantiomers (N-TFA Derivatives) on Astec® CHIRALDEX® B-DA

From our library of Articles, Sigma-Aldrich presents GC Analysis of Fluoxetine Enantiomers (N-TFA Derivatives) on Astec® CHIRALDEX® B-DA
Keywords: Chromatography, Clinical, Flame ionization detector, Forensic, Gas chromatography, Pharmaceutical, Purification

Peer-Reviewed Papers
15

References

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