• USA Home
  • F1927 - Fibroblast Growth Factor Receptor 2β (IIIb)/Fc Chimera from mouse

F1927 Sigma

Fibroblast Growth Factor Receptor 2β (IIIb)/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym: FGFR-2β (IIIb)/Fc Chimera



Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, FGF Receptors,
recombinant   expressed in baculovirus infected Sf21 cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 56 kDa
  mol wt ~74 kDa by SDS-PAGE
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Fgfr2(14183)


Analysis Note

The biological activity is measured by its ability to inhibit human FGF1-dependent proliferation of NR6 cells.

Biochem/physiol Actions

Extracellular domain of one variant of the multiple forms of the receptor for FGF. Its IgIII domain differs from that FGFR-2β (IIIc) due to alternative splicing. Possesses a higher affinity for FGF1 than for FGF2.

FGFR2 (fibroblast growth factor receptor 2) facilitates tumor growth, invasiveness, metastasis and angiogenesis. It plays an essential role in the development of mammary glands, and its expression is elevated in breast cancers. Studies in North Indian population suggest that polymorphisms in this gene might be linked to susceptibility to breast cancer. It is anti-apoptotic in nature, and suppresses p53-mediated apoptosis, by inducing the elevation of MDM2 levels. Mutations in this gene are linked to mild Crouzon syndrome and craniosynostosis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

General description

FGFR2 (fibroblast growth factor receptor 2) is a member of the tyrosine kinase receptor family called FGFR. This gene is localized to human chromosome 10q26, and is composed of 2 exons. Its ligand-binding domain in present in its extracellular region, which is composed of three immunoglobulin (Ig)-like domains. It spans the membrane once, and its tyrosine kinase domain is localized to its intracellular region. Alternative splicing of this gene gives rise to two isoforms- epithelial (FGFR2IIIb) and mesenchymal (FGFR2IIIc).

Price and Availability

All labs need water
Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?