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F2379 Sigma-Aldrich

Fetuin from fetal bovine serum

lyophilized powder, suitable for cell culture

Synonym: Fetuin from fetal calf serum

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Properties

Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Fetuin, Plasma & Blood Proteins,
Quality Level   200
biological source   bovine serum (fetal)
form   lyophilized powder
application(s)   cell culture | mammalian: suitable
impurities   ≤0.3% free N-acetylneuraminic acid
solubility   H2O: 1 mg/mL, colorless to faint yellow or tan
storage temp.   2-8°C
Gene Information   bovine ... FETUB(504615)

Description

General description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Application

Fetuin from fetal bovine serum has been used:
• to synthesize primary and secondary calciprotein particles (CPP)
• to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
• as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Packaging

1, 5, 25 g in poly bottle

100, 250 mg in poly bottle

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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