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F3503 Sigma-Aldrich

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt

~85%

Synonym: FdUMP

  • CAS Number 103226-10-4

  • Empirical Formula (Hill Notation) C9H12FN2O8P

  • Molecular Weight 326.17

  •  MDL number MFCD00057409

  •  PubChem Substance ID 24894845

  •  NACRES NA.51

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Properties

Related Categories Biochemicals and Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotide Analogs More...
Quality Level   200
assay   ~85%
form   solid
storage temp.   −20°C
SMILES string   [Na].OC1CC(OC1COP(O)(O)=O)N2C=C(F)C(=O)NC2=O
InChI   1S/C9H12FN2O8P.Na.H/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18;;/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18);;
InChI key   DGEOOGBABXVZPJ-UHFFFAOYSA-N

Description

Application

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt has been used as an anti-mitotic agent and is used extensively in studies on the activity and function of thymidylate synthase (TS).

Packaging

25 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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