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F3804 Sigma-Aldrich

Anti-Frizzled-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-FZD1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies for Neural Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human kidney
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
availability   not available in Japan
UniProt accession no.   Q9UP38
Gene Information   human ... FZD1(8321)
mouse ... Fzd1(14362)
rat ... Fzd1(58868)

Description

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-1, conjugated KLH. The immunizing peptide has 85% homology with the rat and mouse gene.

Application

Anti-Frizzled-1 antibody is suitable for immunohistochemistry studies (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL, using human kidney.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. Frizzled 1 (FZD1) protein is an essential component of the Wnt/β-catenin pathway. It is expressed in heart, kidney, lung, ovary, pancreas, placenta, and prostate. It has been reported that, FZD1 is up-regulated in several cancers including colon, ovarian, breast neuroblastoma.

Safety & Documentation

Safety Information

WGK Germany 
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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Cancer Stem Cells: New Targets for Cancer Therapy

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Keywords: Cancer, Cell attachment, Cell culture, Cell proliferation, Gastrointestinal, Gene expression, Transcription, transformation

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Peer-Reviewed Papers
15

References

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