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  • F3901 - Monoclonal Anti-Interleukin-4−Carboxyfluorescein antibody produced in mouse

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F3901 Sigma-Aldrich

Monoclonal Anti-Interleukin-4−Carboxyfluorescein antibody produced in mouse

clone 3007.11, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-IL-4, Monoclonal Anti-Interleukin-4

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Intracellular Cytokine Staining, Antibodies to Interleukins and Receptors,
conjugate   carboxyfluorescein conjugate
clone   3007.11, monoclonal
biological source   mouse
application(s)   flow cytometry: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
antibody form   purified immunoglobulin
isotype   IgG1
antibody product type   primary antibodies
storage condition   protect from light
UniProt accession no.   P05112
Gene Information   human ... IL4(3565)

Description

Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.

Immunogen

recombinant human IL-4

Physical form

Solution in saline containing up to 0.5% bovine serum albumin and up to 0.1% of sodium azide as a preservative.

Packaging

100 test in glass bottle

Biochem/physiol Actions

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The signaling stimulated by IL-4 by binding to its receptors leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 mediates endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. The coupling of Carboxyfluorescein to Anti-Interleukin-4 antibody allows for flow cytometry applications.

Preparation Note

Purified antibody is conjugated to carboxyfluorescein (FITC).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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