F3917 Sigma


For use in molecular biology applications

Synonym: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin



Related Categories Biochemicals, Biochemicals and Reagents, Isoprenoids, Lipids, Molecular Biology,
biological source   Coleus forskohlii
description   for activation of T cells
product line   BioReagent
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: 5 mg/mL (stable at least 6 months at room temperature)(lit.)
  ethanol: soluble
suitability   suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells
storage temp.   room temp


Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.


10, 25 mg in poly bottle

General description

Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii.

Price and Availability

LC-MS Grade Solvents and Reagents

Fatty Acid Extraction Kit

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Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
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Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
How should I store a DMSO or ethanol solution of Product F3917, Forskolin?
Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.
How can I make an aqueous solution of Product F3917, Forskolin?
Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.
Will residual solvents inhibit forskolin activation of adenylate cyclase?
Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.
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Protocols & Articles


Forskolin from Coleus forskohlii

T-cell activation is normally triggered by the interaction of a cell surface receptor to its specific ligand molecule. This binding event triggers the rapid hydrolysis of inositol phospholipids to di...
Keywords: Addition reactions, Centrifugation, Culture media, Enzyme-linked immunosorbent assay, Ligands, Phosphorylations

Peer-Reviewed Papers


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