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F5631 Sigma-Aldrich

Fucoidan from Fucus vesiculosus


Synonym: Fucoidin



Related Categories Carbohydrates, Cell Biology, Functional Foods, Nutrition Research, Polysaccharide More...
Quality Level   200
biological source   algae (Fucus Vesiculosus)
form   powder
quality   Crude
solubility   H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow


General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.


Fucoidan from Fucus vesiculosus may be used as a biological response modifier and as a potential therapeutic agent with a wide range of biological activities. It may be used to study its pharmacokinetics, safety, efficacy and methods of delivery as a potential anticancer, anti-immune and anti-inflammatory agent. Fucoidan may be used to assess its potential and formulations for tissue engineering applications.


1 g in poly bottle

500 mg in poly bottle

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Preparation Note

Prepared by a modification of the method of Black, W.A.P., et al., J. Sci. Food Agri., 3, 122 (1952).

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

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Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the molecular weight of Product F5631, Fucoidan from Fucus vesiculosus?
The molecular weight of the F5631 is assayed on a lot-by-lot basis. The molecular weight will be reported on the certificate of analysis for each lot of product.
What is the solubility of Product F5631, Fucoidan from Fucus vesiculosus?
The F5631 is water-soluble. It is tested for solublity in water at 10mg/mL; this yields a clear to hazy, yellow to amber solution.
What is the purity of Product F5631, Fucoidan from Fucus vesiculosus?
The F5631 is not tested for purity or to identify possible impurities. It is a crude fucoidan from Fucus vesiculosus.
Is there information about the structure of Product F5631, Fucoidan from Fucus vesiculosus?
In general, fucoidin is a branched polymer of L-fucose monosulfate joined predominately by 1,2 linkages. Fucoidin is also known in the literature as fucan. The properties are discussed further by Bernardi and Springer in J. Biol. Chem, 237, 75-80 (1962); the title of the article is "Properties of highly purified fucan".
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