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F6771 Sigma-Aldrich

Fumagillin from Aspergillus fumigatus

≥90%, powder

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Properties

Related Categories Angiogenesis, Angiogenesis Inhibitors, Angiogenesis Regulators, Antibiotics, Antibiotics A to Z,
Quality Level   200
biological source   Aspergillus sp. (Aspergillus fumigatus)
assay   ≥90%
form   powder
color   white
mp   197-198  °C
solubility   ethanol: 1 mg/mL
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   fungi
storage temp.   −20°C
SMILES string   COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
InChI   1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
InChI key   NGGMYCMLYOUNGM-HCNIIHBUSA-N

Description

General description

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.

Application

Fumagillin from Aspergillus fumigatus has been used:
• in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
• to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
• as a positive control in in vitro and ex vivo studies

Packaging

1, 5 mg in serum bottle

Biochem/physiol Actions

Fumagillin is known to be effective against microsporidian fungal infections.

Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
HE1750000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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