F6886 Sigma


from Coleus forskohlii, ≥98% (HPLC), powder

Synonym: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin



Related Categories Adenylyl Cyclase Activators, Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
biological source   Coleus forskohlii
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   DMSO: 5 mg/mL (stable at least 6 months at room temperature)
  ethanol: soluble
Gene Information   human ... OPRK1(4986), SLC2A10(81031), TNF(7124)


Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.


10, 25, 50 mg in poly bottle

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Price and Availability

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Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Protocols & Articles


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Gabi Tremml, Ming Li and Vi Chu1*,
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