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F6889 Sigma-Aldrich

Famotidine

Synonym: N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

  • CAS Number 76824-35-6

  • Empirical Formula (Hill Notation) C8H15N7O2S3

  • Molecular Weight 337.45

  •  MDL number MFCD00079297

  •  PubChem Substance ID 24278442

  •  NACRES NA.77

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Properties

Related Categories Antagonists- Histaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
originator   Johnson & Johnson
SMILES string   N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
InChI   1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChI key   XUFQPHANEAPEMJ-UHFFFAOYSA-N
Gene Information   human ... HRH2(3274)

Description

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Biochem/physiol Actions

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.

H2 histamine receptor antagonist; anti-ulcer agent

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
UA2300000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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