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F7131 Sigma-Aldrich

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

Synonym: FAPGG, N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine

  • CAS Number 64967-39-1

  • Empirical Formula (Hill Notation) C20H21N3O6

  • Molecular Weight 399.40

  •  MDL number MFCD00036816

  •  PubChem Substance ID 24894929

  •  NACRES NA.32

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Properties

Related Categories Angiotensin Converting Enzyme, Angiotensin Metabolism, Angiotensins, Biochemicals and Reagents, Cell Biology,
Quality Level   200
storage temp.   −20°C
SMILES string   OC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c2ccco2
InChI   1S/C20H21N3O6/c24-17(9-8-15-7-4-10-29-15)23-16(11-14-5-2-1-3-6-14)20(28)22-12-18(25)21-13-19(26)27/h1-10,16H,11-13H2,(H,21,25)(H,22,28)(H,23,24)(H,26,27)/b9-8+/t16-/m0/s1
InChI key   ZDLZKMDMBBMJLI-FDMDGMSGSA-N
Gene Information   human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

Description

Amino Acid Sequence

FA-Phe-Gly-Gly

General description

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly acts as a substrate for angiotensin converting enzyme (ACE), and is used in inhibitory assays of ACE.

Application

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly has been used for kinetic spectrophotometric assay of ACE (angiotensin converting enzyme) inhibitory activity.

Packaging

25, 100, 500 mg in poly bottle

Substrates

A substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Peer-Reviewed Papers
15

References

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