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F7553 Sigma-Aldrich

FR 122047 hydrochloride

≥98% (HPLC), powder

Synonym: 1-[(4,5-Bis(4-methoxyphenyl)-2-thiazoyl)carbonyl]-4-methylpiperazine hydrochloride

  • CAS Number 130717-51-0

  • Empirical Formula (Hill Notation) C23H25N3O3SHCl

  • Molecular Weight 459.99

  •  MDL number MFCD00925604

  •  PubChem Substance ID 24724483

  •  NACRES NA.77

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Properties

Related Categories A to C, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
biological source   synthetic (organic)
assay   ≥98% (HPLC)
form   powder
color   faintly yellow
solubility   methylene chloride: 50 mg/mL, slightly hazy, yellow
shipped in   wet ice
storage temp.   2-8°C
SMILES string   Cl[H].COc1ccc(cc1)-c2nc(sc2-c3ccc(OC)cc3)C(=O)N4CCN(C)CC4
InChI   1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
InChI key   YWMAVHIKOAOSFM-UHFFFAOYSA-N

Description

Packaging

25 mg in glass bottle

Biochem/physiol Actions

Selective cyclooxgenase-1 (COX-1) inhibitor.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

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