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F7876 Sigma-Aldrich

Folic acid

≥97%

Synonym: PteGlu, Pteroyl-L-glutamic acid, Vitamin M

  • CAS Number 59-30-3

  • Empirical Formula (Hill Notation) C19H19N7O6

  • Molecular Weight 441.40

  •  Beilstein/REAXYS Number 100781

  •  EC Number 200-419-0

  •  MDL number MFCD00079305

  •  eCl@ss 34058014

  •  PubChem Substance ID 57654192

  •  NACRES NA.79

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Biochemicals and Reagents, Cell Biology,
biological source   synthetic (organic)
InChI Key   OVBPIULPVIDEAO-LBPRGKRZSA-N
assay   ≥97%
form   powder
application(s)   HPLC: suitable
color   faint orange to dark orange-yellow
  faint yellow to dark yellow
mp   > 285 °C
storage temp.   room temp

Description

Application

Folic acid has been used:
• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Packaging

1, 10, 25, 100 g in glass bottle

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
LP5425000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Folic Acid Metabolism: A Role in Cancer's Cause and Cure

The mammalian folic acid cycle is a highly complex but crucial process for the transfer of one-carbon units to amino acids, nucleotides, and other biomolecules. Folic acid cannot be synthesized but i...
Biofiles Vol. 5, No. 6
Keywords: Antibiotics, Antitumor agents, Apoptosis, Building blocks, Cancer, Cellular processes, Eliminations, Gastrointestinal, Metabolic Pathways, Metabolism, Metabolites, Methylations, Phosphorylations, Purine synthesis, Reductions, transformation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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