F8758 Sigma-Aldrich

Folic acid

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Synonym: PteGlu, Pteroyl-L-glutamic acid, Pterylmonoglutamic acid, Vitamin M

  • CAS Number 59-30-3

  • Empirical Formula (Hill Notation) C19H19N7O6

  • Molecular Weight 441.40

  •  Beilstein/REAXYS Number 100781

  •  EC Number 200-419-0

  •  MDL number MFCD00079305

  •  eCl@ss 34058014

  •  PubChem Substance ID 24894973

  •  NACRES NA.75



Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids and Vitamins, Biochemicals and Reagents,
Quality Level   200
biological source   synthetic
product line   BioReagent
assay   ≥97%
form   powder
mol wt   Mw 441.40 g/mol
application(s)   cell culture | insect: suitable
  cell culture | mammalian: suitable
  cell culture | plant: suitable
color   dark yellow
solubility   1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange
storage temp.   room temp
SMILES string   NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2N1
InChI   1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1


General description

Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).


Folic acid has been used:
• to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
• in cells and treatments
• in perforin gene targeting using the CRISPR/Cas gene editing approach


5, 25 g in glass bottle

Biochem/physiol Actions

A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8758.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solubility of folic acid (Product No. F8758)?
Product No. F8758 is soluble in 1 M NaOH (50 mg/mL). The free acid is only slightly soluble in water (0.01 mg/mL at 0 °C), and is insoluble in aqueous solutions below pH 5. It is soluble in sodium bicarbonate or sodium hydroxide solutions.
What is the stability of folic acid (Product No. F8758) once in solution?
This product is photolabile and is inactivated by UV light. Alkaline solutions are reasonably stable in the dark, but heating will destroy both alkaline and acidic solutions.
Is Product No. F8758,Folic Acid,tested for endotoxins?
No, Product No. F8758 has not been tested for endotoxins. This product has, however, been tested for use in mammalian cell culture and insect cell culture.
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