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F8807 Sigma-Aldrich

FM19G11

≥98% (HPLC)

Synonym: [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate, 3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester

  • CAS Number 329932-55-0

  • Empirical Formula (Hill Notation) C23H17N3O8

  • Molecular Weight 463.40

  •  MDL number MFCD01174289

  •  PubChem Substance ID 329799774

  •  NACRES NA.77

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Metabolism, Cancer Research,
InChI Key   XVUOIWIIQVGWAJ-UHFFFAOYSA-N
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   off-white to light brown
solubility   DMSO: ≥40 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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