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F9505 Sigma-Aldrich

Furazolidone

Synonym: 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone

  • CAS Number 67-45-8

  • Empirical Formula (Hill Notation) C8H7N3O5

  • Molecular Weight 225.16

  •  Beilstein/REAXYS Number 8317414

  •  EC Number 200-653-3

  •  MDL number MFCD00010550

  •  PubChem Substance ID 24894997

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
biological source   synthetic
InChI Key   PLHJDBGFXBMTGZ-WEVVVXLNSA-N
form   powder
color   yellow
mp   256-256 °C
solubility   formic acid: 50 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
  parasites

Description

Application

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.

Packaging

10, 25, 100 g in glass bottle

Biochem/physiol Actions

Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RQ3675000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

HPLC Analysis of Antiprotozoal Drugs on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antiprotozoal Drugs on Ascentis® Phenyl
Keywords: Antibiotics, Antiprotozoals, Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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