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  • G0416 - Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C2′) antibody produced in rabbit

G0416 Sigma

Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C2′) antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   mouse, rat
application(s)   immunoprecipitation (IP): 1:200
  western blot: 1:1000 using rat and mouse brain homogenates and HEK 293 cells
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
mol wt   antigen mol wt 100 kDa
storage temp.   2-8°C
Gene Information   mouse ... Grin1(14810)
rat ... Grin1(24408)
biological source   rabbit
conjugate   unconjugated



synthetic peptide representing the sequence of the C2′ splice variant.

Physical form

Lyophilized powder from 5 mM ammonium bicarbonate (some residual salt may be present)


Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C2′) antibody is suitable for immunoprecipitation at a dilution of 1:200 and western blot at a dilution of 1:1000 using rat and mouse brain homogenates and HEK 293 cells.

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Biochem/physiol Actions

NMDA receptors (NMDAR) are glutamate-gated ion channels. It is sensitive to N-methyl-D-aspartate (NMDA) and consists of several homologous subunits (NMDAR1). NMDAR is highly expressed in the central nervous system and involved in excitatory synaptic transmission as well as synaptic plasticity. The activity of NMDA receptors are modulated by glycine. It exhibits high calcium permeability and unique voltage-dependent sensitivity to magnesium. It has been reported that phosphorylated NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation.

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Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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