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G0657 Sigma-Aldrich

GROα human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: MGSA, Melanoma Growth Stimulating Activity

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation,
biological source   human
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
potency   2.0-5.0 ng/mL
mol wt   mol wt ~7.9 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
suitability   cell culture tested
UniProt accession no.   P09341
storage temp.   −20°C
Gene Information   human ... CXCL1(2919)

Description

Analysis Note

The biological activity is measured by its ability to induce chemotaxis of mouse BaF/3 cells transfected with hCXCR2.

Physical form

Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

Biochem/physiol Actions

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), plays an essential role in neutrophil recruitment, and the initiation of angiogenesis. This gene is up-regulated in multiple cancer types such as, gastric cancer, renal cell carcinoma, prostate cancer and melanoma. The expression of this protein is also elevated in HER2 positive metastatic breast cancer. Its expression is increased in fibroblasts, which might be involved in breast tumor progression, and its stromal expression in breast cancer is linked to poor prognosis. This gene is also up-regulated in the aggressive phenotype of bladder cancer. Polymorphism rs4074 A in this gene is also associated with susceptibility to alcoholic cirrhosis.

General description

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), is a member of the small soluble chemokine protein family. It belongs to the C-X-C subfamily, which is comprised of 17 members. It contains a conserved glutamic acid-leucine-arginine (ELR) domain. This protein is expressed on stromal cells such as, endothelial cells, fibroblasts and blood-circulating cells.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2

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Protocols & Articles
Peer-Reviewed Papers
15

References

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