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  • G0666 - Anti-Glycine Receptor antibody produced in rabbit

G0666 Sigma-Aldrich

Anti-Glycine Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to GABA and Glycine Receptors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunoprecipitation (IP): suitable
  western blot: suitable using rat spinal cord and cell extracts containing the recombinant human glycine receptors
species reactivity   human, rat
form   lyophilized powder
storage temp.   2-8°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P23415
Gene Information   human ... GLRA1(2741), GLRA2(2742)
rat ... Ptk2(25674)


General description

The GLRA1 (glycine receptor α 1) gene is mapped to human chromosome 5q33.1. Glycine receptor is a pentameric Cys-loop ligand-gated ion channel. It is a transmembrane protein, with its five subunits arranged around a central water-filled Cl−selective pore. The protein is expressed all over the nervous system. Each of its subunit contains four transmembrane (TM) segments with an intracellular loop connecting TM3 and TM4, and an extracellular ligand binding domain.


The antibody recognizes the α1 glycine receptor and cross-reacts with human α2 glycine receptor subunits.


synthetic peptide from the amino terminus of the human α1 glycine receptor subunit.


Anti-Glycine Receptor antibody is suitable for western blot analysis of immunoprecipitates of rat spinal cord (lane 2) and human sperm extract in the detection of GlyR in human sperm.

Physical form

Lyophilized powder from 5 mM ammonium bicarbonate.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Glycine receptors act as excitatory neurotransmitter as well as inhibitory receptor. It plays a central role in acrosome reaction (AR). Mutations in the GLRA1 gene encoding the α1-subunit of the glycine receptor causes startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.

Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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