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  • G0666 - Anti-Glycine Receptor antibody produced in rabbit

G0666 Sigma

Anti-Glycine Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to GABA and Glycine Receptors,
species reactivity   human, rat
application(s)   immunoprecipitation (IP): suitable
  western blot: suitable using rat spinal cord and cell extracts containing the recombinant human glycine receptors
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   2-8°C
Gene Information   human ... GLRA1(2741), GLRA2(2742)
rat ... Ptk2(25674)
biological source   rabbit
conjugate   unconjugated



synthetic peptide from the amino terminus of the human α1 glycine receptor subunit.

Physical form

Lyophilized powder from 5 mM ammonium bicarbonate.


The antibody recognizes the α1 glycine receptor and cross-reacts with human α2 glycine receptor subunits.


Anti-Glycine Receptor antibody is suitable for western blot analysis of immunoprecipitates of rat spinal cord (lane 2) and human sperm extract in the detection of GlyR in human sperm.

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Biochem/physiol Actions

Glycine receptors act as excitatory neurotransmitter as well as inhibitory receptor. It plays a central role in acrosome reaction (AR). Mutations in the GLRA1 gene encoding the α1-subunit of the glycine receptor causes startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.

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Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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