G1251 Sigma-Aldrich

L-Glutamic acid

ReagentPlus®, ≥99% (HPLC)

Synonym: (S)-2-Aminopentanedioic acid, Glu

  • CAS Number 56-86-0

  • Linear Formula HO2CCH2CH2CH(NH2)CO2H

  • Molecular Weight 147.13

  •  Beilstein/REAXYS Number 1723801

  •  EC Number 200-293-7

  •  MDL number MFCD00002634

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895052

  •  NACRES NA.26



Related Categories Allium sativum (Garlic), Aloe Vera, Amino Acids, Asymmetric Synthesis, Biochemicals and Reagents,
Quality Level   200
product line   ReagentPlus®
assay   ≥99% (HPLC)
form   powder
application(s)   microbiological culture: suitable
color   white to off-white
mp   205 °C (dec.) (lit.)
solubility   1 M HCl: soluble 100 mg/mL
density   1.54 g/cm3 at 20 °C
cation traces   C: 40.4-41.2%
  N: 9.2-9.8%
SMILES string   N[C@@H](CCC(O)=O)C(O)=O
InChI   1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
Gene Information   human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)



L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.


1 kg in poly bottle

100, 500 g in poly bottle

5 kg in poly drum

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

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Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Protocols & Articles


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