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G1660 Sigma-Aldrich

Galanthamine hydrobromide from Lycoris sp.

≥94% (HPLC)

Synonym: Galantamine hydrobromide

  • CAS Number 1953-04-4

  • Empirical Formula (Hill Notation) C17H21NO3 · HBr

  • Molecular Weight 368.27

  •  EC Number 217-780-5

  •  MDL number MFCD00067672

  •  PubChem Substance ID 24895074

  •  NACRES NA.32

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Properties

Related Categories A to C, Acetylcholinesterase, Analytical and Industrial Enzymes, Biochemicals and Reagents, Cell Biology,
Quality Level   100
biological source   plant (Ungeria victoris)
assay   ≥94% (HPLC)
form   powder
mp   270  °C
solubility   DMSO: soluble 10 mg/mL, clear, colorless
  water: soluble 20 mg/mL, clear, colorless
storage temp.   −20°C
SMILES string   Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
InChI   1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChI key   QORVDGQLPPAFRS-XPSHAMGMSA-N
Gene Information   human ... ACHE(43)

Description

General description

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer’s disease (AD).

Application

Galanthamine hydrobromide from Lycoris sp. has been used-
• as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
• as a positive control in the screening of AChE inhibitors
• as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides

Biochem/physiol Actions

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
DF8075000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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