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G4753 Sigma

Griseofulvin

from Penicillium griseofulvum, 97.0-102.0%

Synonym: (2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione

  • CAS Number 126-07-8

  • Empirical Formula (Hill Notation) C17H17ClO6

  • Molecular Weight 352.77

  •  Beilstein Registry Number 95226

  •  EC Number 204-767-4

  •  MDL number MFCD00082343

  •  PubChem Substance ID 24895185

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Bioactive Small Molecule Alphabetical Index,
biological source   Penicillium griseofulvum
InChI Key   DDUHZTYCFQRHIY-RBHXEPJQSA-N
assay   97.0-102.0%
form   powder
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   fungi
storage temp.   −20°C

Description

Biochem/physiol Actions

Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division. Induces apoptosis in human tumor cell lines.

Packaging

5, 25, 50 g in poly bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WG9800000

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

Antifungals

Antifungal compounds have been overshadowed by antibacterials in research interest and application due to the greater impact bacterial infections have had on health. Resistance to antibacterial drugs...
Chloe McClanahan
BioFiles 2009, 4.3, 10.
Keywords: Antibiotics, Antifungals, Cellular processes, Clinical, Fungicides, Gene expression, Research Reports, Transcription

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Peer-Reviewed Papers
15

References

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