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  • G5544 - Anti-GABAA Receptor (α6 subunit) antibody produced in rabbit

G5544 Sigma-Aldrich

Anti-GABAA Receptor (α6 subunit) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-γ-Aminobutyric Acid Type A Receptor (α6 subunit), Anti-GABRA6



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to GABA and Glycine Receptors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:200 using rat brain membranes
species reactivity   rat
form   lyophilized powder
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P30191
Gene Information   human ... GABRA6(2559)
mouse ... Gabra6(14399)
rat ... Gabra6(29708)


General description

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.


peptide corresponding to amino acids 20-37 of rat GABA(A) α6. This sequence is identical in mouse and shares 17 of 19 residues in human.


Anti-GABAA Receptor (α 6 subunit) antibody produced in rabbit is suitable for the immunofluorescent detection of GABAA receptor α 6 in cerebella of mice. It is suitable for immunoblotting at a working dilution of 1:200 using rat brain membranes.

Target description

Anti-GABA(A) Receptor (α6 subunit) specifically recognizes the GABA(A) receptor α6 subunit protein and may be used for the detection of the GABA(A) receptor α6 subunit protein. The inhibitory neurotransmitter GABA (α-aminobutyricacid

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Mutations in the gene may be responsible for the pathogenesis of childhood absence epilepsy (CAE). Polymorphism in this gene is also related to attenuation in hormonal and blood pressure responses under certain psychological stress.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

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