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G5667 SAFC

L-Glutamic acid

PharmaGrade, Ajinomoto, EP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Synonym: (S)-2-Aminopentanedioic acid, Glu

  • CAS Number 56-86-0

  • Linear Formula HO2CCH2CH2CH(NH2)CO2H

  • Molecular Weight 147.13

  •  Beilstein/REAXYS Number 1723801

  •  EC Number 200-293-7

  •  MDL number MFCD00002634

  •  PubChem Substance ID 24895223

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z,
biological source   non-animal source
Agency/Method   EP
product line   PharmaGrade
assay   98.5-100.5% dry basis
form   crystalline powder
mfr. no.   Ajinomoto
storage condition   room temperature
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, heavy metals, residual solvents, tested
mp   205 °C (dec.) (lit.)
solubility   1 M HCl: 100 mg/mL
density   1.54 g/cm3 at 20 °C
anion traces   chloride (Cl-): ≤200 ppm
  sulfate (SO42-): ≤0.020%
cation traces   As: ≤1.0 ppm
  Fe: ≤10 ppm
  NH4+: ≤200 ppm
suitability   suitable for manufacturing use
Featured Industry   Pharmaceutical (small molecule)
foreign activity   cytotoxicity, tested
storage temp.   room temp
SMILES string   N[C@@H](CCC(O)=O)C(O)=O
InChI   1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChI key   WHUUTDBJXJRKMK-VKHMYHEASA-N
Gene Information   human ... CCR2(1231), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.
To request the Enhanced Quality Product Documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement.

Application

L-Glutamic acid is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Legal Information

Ajinomoto is a registered trademark of Ajinomoto North America, Inc.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

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Peer-Reviewed Papers
15

References

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