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G6752 Sigma-Aldrich

Guanosine

≥98%

Synonym: 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside

  • CAS Number 118-00-3

  • Empirical Formula (Hill Notation) C10H13N5O5

  • Molecular Weight 283.24

  •  Beilstein/REAXYS Number 625911

  •  EC Number 204-227-8

  •  MDL number MFCD00010182

  •  PubChem Substance ID 24895268

  •  NACRES NA.51

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Properties

Related Categories Allium sativum (Garlic), Biochemicals and Reagents, Cell Biology, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides,
Quality Level   100
biological source   microbial
assay   ≥98%
form   powder
mp   250 °C (dec.) (lit.)
solubility   formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
SMILES string   [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI   1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChI key   NYHBQMYGNKIUIF-UUOKFMHZSA-N

Description

General description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Application

Guanosine has been used:
• as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
• as a component of Mouse Embryonic Fibroblasts (MEFs) culture
• as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Packaging

1, 25, 100, 500 g in poly bottle

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Safety & Documentation

Safety Information

RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
MF8750000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Nucleosides on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Phenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Nucleosides on Ascentis® Si (Silica)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Si (Silica)
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Ribonucleosides on Ascentis® Si

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ribonucleosides on Ascentis® Si
Keywords: Chromatography, High performance liquid chromatography

LC/MS Analysis of Nucleosides on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleosides on Ascentis® Express F5
Keywords: Antibiotics, Antivirals, Chromatography, Dimroth rearrangement, Fungicides, Genetic, Herbicides, High performance liquid chromatography, Industries, Insecticides, Liquid chromatography mass spectrometry, Mass spectrometry, Rearrangements

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

TLC Analysis of Nucleosides on HPTLC Silica gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Nucleosides on HPTLC Silica gel 60 RP-18 WF254s
Keywords: Chromatography, Thin layer chromatography

UHPLC Analysis of Nucleosides on Purospher® STAR RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Nucleosides on Purospher® STAR RP-18 endcapped
Keywords: Antibiotics, Antivirals, Fungicides, Genetic, Herbicides, High performance liquid chromatography, Industries, Insecticides

UHPLC/MS Analysis of 8-Hydroxy-2′-Deoxyguanosine and Related Compounds on Titan™ Silica

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of 8-Hydroxy-2′-Deoxyguanosine and Related Compounds on Titan™ Silica
Keywords: Chromatography, Mass spectrometry, Separation

Peer-Reviewed Papers
15

References

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