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G7298 Sigma-Aldrich

Gatifloxacin synthetic

Synonym: (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sesquihydrate sesquihydrate, Gatifloxacin, Tequin®

  • Empirical Formula (Hill Notation) C19H22FN3O4 · 1.5H2O

  • Molecular Weight 402.42

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents
biological source   synthetic
assay   ≥98% (HPLC)
form   powder or solid
color   white to light yellow
mp   162 °C
solubility   1 M NaOH: 10 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   room temp

Description

General description

Gatifloxacin is a fourth-generation fluoroquinolone which inhbits DNA gyrase and topoisomerase.

Application

Gatifloxacin is a fluoroquinolone antibiotic clinically used to treat bronchitis, sinusitis, community-acquired pneumonia and skin infections. It is used to study potential side effects such as hyperglycemia, seizures and dysglycemia. It is used to study multidrug-resistant organisms.

Packaging

1 g in poly bottle

Biochem/physiol Actions

Gatifloxacin is a fourth-generation fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase, which are necessary for DNA replication, transcription, repair and recombination. It has 100 times higher affinity for bacterial DNA gyrase than for mammalian DNA gyrase. Gatifloxacin is active against both Gram-positive and Gram-negative bacteria.

Legal Information

Tequin is a registered trademark of Bristol-Myers Squibb Co.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
VB1983600

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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