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  • G8044 - Anti-phospho-GATA4 (pSer105) antibody produced in rabbit

G8044 Sigma-Aldrich

Anti-phospho-GATA4 (pSer105) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins, Bioactives, Markers, and Receptors for Stem Cell Biology, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cardiac Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:500
species reactivity   mouse
mol wt   antigen 46 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −70°C
packaging   pkg of (1 vl = 100ul)
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
UniProt accession no.   Q08369
Gene Information   human ... GATA4(2626)
mouse ... Gata4(14463)
rat ... Gata4(54254)



Anti-phospho-GATA4 (pSer105) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.

synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

Physical form

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser105 of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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