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  • G8294 - Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit

G8294 Sigma-Aldrich

Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neuropeptides, GM-GO,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 1 μg/mL using mouse embryo brain
species reactivity   mouse
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   P13562
Gene Information   human ... GNRH1(2796)
mouse ... Gnrh1(14714)
rat ... Gnrh1(25194)



synthetic peptide pyroEHWSYGLRP(G-NH2) corresponding to human GnRH. The sequence is completely conserved in rat and tree shrew and 78% conserved in zebrafish.


Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit is suitable for immunoprecipitation of GnRH purified from adult amphioxus tissues. It is suitable for immunohistochemistry at a working concentration of 1μg/mL using mouse embryo brain.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Physical form

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Gonadotropin releasing hormone (GnRH) is crucial for the regulation of reproduction in vertebrates. It is a decapeptide and is expressed by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. Neural, hormonal and environmental stimuli affect the generation of GnRH pulses, which in turn affect the secretion of follicle stimulating hormone(FSH) and luteinizing hormone (LH) from the pituitary. It may be involved in mediating cancers of the reproductive system.

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers


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