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G8377 Sigma-Aldrich

Guanosine 5′-monophosphate disodium salt hydrate

from yeast, ≥99%

Synonym: 5′-GMP-Na2, 5′-Guanylic acid disodium salt hydrate

  • CAS Number 5550-12-9

  • Empirical Formula (Hill Notation) C10H12N5Na2O8P · xH2O

  • Molecular Weight 407.18 (anhydrous basis)

  •  Beilstein/REAXYS Number 3586801

  •  EC Number 226-914-1

  •  MDL number MFCD00151238

  •  PubChem Substance ID 24895338

  •  NACRES NA.51

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Properties

Related Categories Cell Biology, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide More...
Quality Level   100
biological source   yeast
assay   ≥99%
solubility   H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
storage temp.   room temp
SMILES string   O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
InChI   1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1
InChI key   MEKWJTZTMVQYSU-CYCLDIHTSA-L

Description

Application

Guanosine 5′-monophosphate is suitable for use in:
• the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure
• the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes
• the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS

Biochem/physiol Actions

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
MF9290000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC
Keywords: Chromatography, High performance liquid chromatography

LC/MS Analysis of Nucleotides SeQuant ZIC-cHILIC – Effect of pH

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides SeQuant ZIC-cHILIC – Effect of pH
Keywords: High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC – Effect of Mobile Phase Buffer Concentration

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC – Effect of Mobile Phase Buffer Concentration
Keywords: High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC
Keywords: Buffers, Building blocks, Chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Reversed-phase chromatography, Separation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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