G8415 Sigma-Aldrich

L-Glutamic acid

from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

Synonym: (S)-2-Aminopentanedioic acid, Glu

  • CAS Number 56-86-0

  • Linear Formula HO2CCH2CH2CH(NH2)CO2H

  • Molecular Weight 147.13

  •  Beilstein/REAXYS Number 1723801

  •  EC Number 200-293-7

  •  MDL number MFCD00002634

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895340



Related Categories Amino Acids, Amino Acids & Vitamins, Amino Acids and Vitamins, Analytical/Chromatography, Asymmetric Synthesis,
biological source   non-animal source
assay   98.5-100.5%
form   powder
impurities   endotoxin, tested
mp   205 °C (dec.) (lit.)
solubility   1 M HCl: 100 mg/mL
suitability   meets EP testing specifications
  suitable for cell culture
Featured Industry   Pharmaceutical (small molecule)
Gene Information   human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)



L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.


1 kg in poly bottle

10 mg in glass bottle

100 g in poly bottle

Biochem/physiol Actions

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


Cell Culture Guide
Protocols & Articles


Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Biofiles, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Support, Transcription

Related Content

Amino Acids Reference Chart

Amino acids are the 21 standard compounds or building blocks that make up peptides and proteins, including DNA. Each amino acid is structured from an amino group and a carboxyl group bound to a tetra...
Keywords: Building blocks, Gene expression, Mass spectrometry

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?