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G8761 Sigma-Aldrich

(±)-Gossypol from cotton seeds

≥95% (HPLC)

Synonym: (±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)

  • CAS Number 303-45-7

  • Empirical Formula (Hill Notation) C30H30O8

  • Molecular Weight 518.55

  •  MDL number MFCD00017352

  •  PubChem Substance ID 24895349

  •  NACRES NA.77



General description

Gossypol is considered as an antifertility agent. It is present in cottonseed as a yellowish pigment. This reactive sesquiterpene aldehyde is present in the family Malvaceae and has a molecular mass of 518.54.


(±)-Gossypol from cotton seeds has been used:
• as a standard to quantify the gossypol content in the extracts of leaves and flower buds
• to study its antifertility effects on spermatogenesis in NMRI mice
• to analyse its impact on human spermatozoa
• to incorporate into the artificial diet for larval rearing


100, 250 mg in glass bottle

Biochem/physiol Actions

Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B4, seukotriene D4, and PAF-acether.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 

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